An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entrySARS-CoV-2 S2에서 파생된 조작된 5나선 번들은 바이러스 진입을 억제하기 위해 혈청학적 pH와 엔도솜 pH 모두에서 사베코바이러스 스파이크를 사전 결합합니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] 5-helix bundle (5HB) acute respiratory syndrome acute respiratory syndrome coronavirus bind binding Broad-spectrum inhibition can not cell membrane construction coronavirus Evidence feature fusion heptad repeat highlighting host cell host cells IC50 infections inhibit neutralize peptide peptides pre-fusion predominant Protein sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S2 SARS-CoV-2 variant SARS-CoV-2 variants serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural basis These data Treatment viral entry viral entry. viral spike virus entry virus infection [DOI] 10.1080/22221751.2022.2095308 PMC 바로가기 [Article Type] Article
Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral EntryArticle Published on 2022-10-142022-11-16 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 binding binding pocket block blocked broad inhibitor candidate cell-cell fusion cellular circulating SARS-CoV-2 variant Compound conformational change conserved coronavirus Critical Entry inhibitor entry inhibitors entry pathway facilitate function glycoprotein host cell Infection inhibitory effect interfere mode of action plasma membrane receptor Receptor binding domain required Ring SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike selective significantly Small molecules spike Spike. subsequent tested the SARS-CoV-2 these compound Tricyclic Trigger viral entry viral spike [DOI] 10.1021/acsinfecdis.1c00658 PMC 바로가기
The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 VariantsArticle Published on 2022-10-122022-11-16 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition association carried Cell cleavage cleavage site cleaved coronavirus D614G D614G mutation Delta dependent on epistasis epistatic interaction evaluate expressing expression increasingly Mutation omicron pandemic pathogenic Potential Protein proteolytic proteolytic cleavage pseudovirions pseudovirus pseudoviruses remained resulting S1 subunit S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 variant Site spike spike mutation spikes Spread stabilizing effect successive wave Transmissibility variant variants variants of concern variants. Viral particles viral spike viral variant virions wild-type Wuhan [DOI] 10.1128/jvi.01301-22 PMC 바로가기
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike proteinArticle Published on 2022-10-042022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome affected Antiviral assays coronavirus coronavirus disease epitope glycoprotein heptad repeat host cell HR2 include inhibit inhibitor interact interfere less membrane membrane fusion Modification monoclonal antibody Mutation N-terminal offer peptide Peptide Inhibitors peptide. peptides performed Protein Receptor binding domain Region related viruses S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Support target the S protein the SARS-CoV-2 the spike protein therapy Vaccine variants viral entry viral membrane viral spike virus infection [DOI] 10.1073/pnas.2210990119 PMC 바로가기
Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2Article Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome addition Analysis binding affinity block Calu-3 caused cell entry complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients docking drug energy transfer evade exhibit Fritillaria functional glycoprotein Hydrogen bond Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction lung cells molecular docking analysis N501Y patients peimine. Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral infection significantly small molecule suggested suppresse the spike protein treatment for COVID-19 Vaccine variant variant spike variants of concern variants of SARS-CoV-2 viral entry viral infection viral infections viral spike viral spike protein VoC VOCs [DOI] 10.1111/jfbc.14354 PMC 바로가기
Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection KineticsArticle Published on 2022-09-122022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome addition analysis B.1 B.1.617.2 BAC BAC mutagenesis backbone Bacterial bronchial epithelial cells Carrying chromosome clinical comparable coronavirus Cytopathic effect disease Efficiency en passant mutagenesis epithelial cell line evaluate generate glycoprotein human lung Infection infectious virus inhibitors isolate isolates Kinetics less Microscopy monoclonal antibody Mutagenesis Mutation neutralization nonstructural proteins nucleocapsid Numerous Post-vaccine Potential progression raise recombinant RNA role SARS-CoV-2 sera severity spike spike mutation spike mutations Spike protein spike protein. Substitution suggested susceptible Syncytia Transmissibility Treatment variant viral fitness viral spike virus Virus life cycle VoC [DOI] 10.3390/v14092017 PMC 바로가기
Immunomolecular assay based on selective virion capture by spike antibody and viral nucleic acid amplification for detecting intact SARS-CoV-2 particlesArticle Published on 2022-09-052022-11-15 Journal: Journal of Nanobiotechnology [Category] SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome aluminum amplification analyses antibody applied Characteristics clinical sample coefficient Complete Complete virions conditions convalescent coronavirus coronavirus disease COVID-19 Critical detect diagnose facilitate Factor glycoprotein Human immunodeficiency virus human serum Immune escape Immunomolecular detection IMPROVE infection risk Influenza isolation rooms limit of detection molecular monoclonal antibody Mutation nucleic acid amplification Outbreaks parameters Patient pseudovirus quantified Quantitative reduced reverse transcription PCR reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 pseudovirus selective specific antibodies spike Spike. stability Vaccine Variation Viral load viral nucleic acid viral spike viral titer virion virions virus virus detection virus isolation viruses [DOI] 10.1186/s12951-022-01558-8 PMC 바로가기
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingArticle Published on 2022-09-022022-11-16 Journal: Human Genomics [Category] SARS, 변종, [키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses [DOI] 10.1186/s40246-022-00411-1 PMC 바로가기
Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts두 개의 다른 코호트에서 상용 SARS-CoV-2 대리 중화 분석과 전체 바이러스 종말점 희석 중화 테스트의 비교Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody titers biosafety level Cohort cohorts convalescent Convalescent SARS-CoV-2-infected individuals COVID COVID vaccinated individuals Cutoff detect Determination Dilution Endpoint Full virus neutralization test glycoprotein gold gold standard indicate infected individuals Infection Interaction labor labor-intensive level 3 neutralization Neutralization assay neutralization test neutralization tests Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Qualitative quantitative measurement RBD Receptor binding domain receptor protein Replication SARS-CoV-2 SARS-CoV-2-infected individual spike glycoprotein surrogate surrogate virus neutralization test Surrogate virus neutralization test. sVNT the RBD vaccinated individuals Viral viral spike virus Virus neutralization virus neutralization test VNT [DOI] 10.1016/j.jviromet.2022.114569 PMC 바로가기 [Article Type] Article
Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages고도로 제한된 SARS-CoV-2 수용체 발현 및 1차 인간 단핵구 및 단핵구 유래 대식세포에 의한 감염에 대한 내성Article Published on 2022-09-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cause caused cellular cellular receptor condition contribute coronavirus COVID-19 Defense direct infection enzyme Express expression facilitated global pandemic immune activation in vitro Infection involved Macrophage macrophages MDM mechanism monocyte monocyte-derived macrophage Monocyte-derived macrophages Monocytes myeloid cell myeloid cells occur Pathogenesis primary human monocyte priming pseudotyped virions receptor remained resistance to infection SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV2 SARS-CoV2 infection Severe acute respiratory syndrome severity spike subtype the disease TMPRSS2 TMPRSS2. unlikely unpolarized viral spike [DOI] 10.1002/JLB.4COVA1121-579RR PMC 바로가기 [Article Type] Article